Human recombinant laminin-111 |
| Murine laminin-111 (laminin-1) is commonly used as a general attachment protein in cell culture and BioLamina now also offers the human recombinant version of laminin-111 |
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Laminin-111 (laminin-1) is important during early epithelial development and differentiation of the epiblast. The laminin α1 chain is expressed by developing epithelial cells at the 16-cell stage in the pre-implantation embryo and remains detectable throughout embryogenesis (Ekblom M et al, 1998). |
 Versatile adhesive substrate |
 Epiblast formation |
 Epithelial cells |
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Laminin-111 (laminin-1) is the laminin isoform found in the the mouse EHS tumor from which Matrigel is extracted. In vitro, laminin-111 supports the survival, proliferation and differentiation of many different cell types, although many of those cultivated cell types would not encounter the protein naturally in vivo. As matrigel is of animal origin and undefined, human recombinant laminin-111 enables better control of your cell matrix. By coating your plate with recombinant laminin you support your cells with a defined and xeno-free substrate. It is unknown why laminin-111 can exert all these major biological effects on such a wide selection of cell types, but one explanation is that, depending on the cell type, the laminin receptors activated by laminin-111 induce different cell signaling cascades. In the adult, laminin α1 chain expression is more restricted to some epithelial basement membranes, and is primarily found in tissues such as the eye, liver and kidney, whereas it is hardly expressed in endothelial, adipose, nervous, and muscle tissues (Ekblom P et al, 2003; Virtanen et al, 2000). |
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