BioLamina products

We offer an expansive portfolio of full-length human recombinant laminin proteins for a variety of cell culture applications in 2D and 3D. Our portfolio of Biolaminin® isoforms provides reliable expansion of pluripotent cells and successful differentiation and maintenance of specialized cell types. The authentic cell culture environment improves cell functionality and allows more consistent and reliable cellular responses.

    All cell culture matrices

    Cell culture matrices

    Almost all cells in the human body grow on specific laminins. With our full-length human recombinant laminin substrates, pluripotent stem cells, adult stem cells, and tissue-specific cells can now be cultured in a physiologically relevant environment, even in 3D culture.

    • Biolaminin 521 LN (LN521)

      Full-length human recombinant laminin-521

      Biolaminin 521 LN is a full-length laminin-521 substrate—the natural laminin for pluripotent stem cells, reliably facilitating ESC and iPSC self-renewal in a chemically defined, xeno-free stem cell culture system. It also uniquely promotes the growth and identity of various tissue-specific human cell types.
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    • Biolaminin 521 MX (MX521)

      Full-length human recombinant laminin-521

      Biolaminin 521 MX is a full-length laminin-521 substrate designed for research aiming for clinical applications.
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    • Biolaminin 521 CTG (CT521)

      Full-length human recombinant laminin-521

      Biolaminin 521 CTG is a full-length laminin-521 substrate designed for clinical applications.
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    • Biolaminin 111 LN (LN111)

      Full-length human recombinant laminin-111

      Biolaminin 111 is a full-length laminin-111 protein—an essential extracellular matrix component for many cell types in vivo. It has proven particularly effective in supporting the differentiation of functional hepatic and neural cells in a chemically defined and xeno-free culture.
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    • Biolaminin 121 LN (LN121)

      Full-length human recombinant laminin-121

      Biolaminin 121 is a full-length human laminin-121 protein that can be used as a general attachment protein for many cell types in vitro.
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    • Biolaminin 211 LN (LN211)

      Full-length human recombinant laminin-211

      Biolaminin 211 supports the growth, survival, and differentiation of a wide range of tissue-specific cell types, including motor neurons, cardiac cells, and skeletal muscle cells.
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    • Biolaminin 221 LN (LN221)

      Full-length human recombinant laminin-221

      Biolaminin 221 supports the growth, survival, and differentiation of a wide range of tissue-specific cell types, including cardiac cells and skeletal muscle cells.
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    • Biolaminin 332 LN (LN332)

      Full-length human recombinant laminin-332

      Biolaminin 332 supports cells in epithelial basement membranes located in several tissues.
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    • Biolaminin 411 LN (LN411)

      Full-length human recombinant laminin-411

      Biolaminin 411 supports diverse tissue cell types such as cells from the pancreas and the vascular, immune, nervous, and hematopoietic systems.
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    • Biolaminin 421 LN (LN421)

      Full-length human recombinant laminin-421

      Biolaminin 421 supports several tissue-specific cell types such as endothelial and kidney cells.
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    • Biolaminin 511 LN (LN511)

      Full-length human recombinant laminin-511

      Biolaminin 511 is the natural laminin for mouse embryonic stem cells, supporting sustained pluripotency without the need for LIF. It also efficiently promotes the culture of many tissue-specific human cell types.
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    • Biosilk 521

      3D culture substrate

      Biosilk 521 is a natural biomaterial made of spider silk and laminin 521 – a biocompatible 3D culture mesh for expansion and long-term differentiation of human pluripotent stem cells and for organoid formation of various cell types.
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    • Biosilk

      3D culture substrate

      Biosilk is a natural biomaterial made of recombinant spider silk protein, a useful tool for a wide range of 3D culture applications, such as organoid culture and other tissue engineering applications. Biosilk can be mixed with any Biolaminin matrix for cell functionality and identity.
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    3D cell culture

    3D cell culture

    Our Biosilk product provides a defined 3D culture network that promotes long-term cell survival without cell encapsulation. The biorelevant Biolaminin substrates can be used together with Biosilk or other 3D cell culture systems for improved cell function.

    • Biosilk 521

      3D culture substrate

      Biosilk 521 is a natural biomaterial made of spider silk and laminin 521 – a biocompatible 3D culture mesh for expansion and long-term differentiation of human pluripotent stem cells and for organoid formation of various cell types.
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    • Biosilk

      3D culture substrate

      Biosilk is a natural biomaterial made of recombinant spider silk protein, a useful tool for a wide range of 3D culture applications, such as organoid culture and other tissue engineering applications. Biosilk can be mixed with any Biolaminin matrix for cell functionality and identity.
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    Cell therapy grade products

    Cell therapy grade products

    Cell therapy grade (CTG) products are designed for clinical research with documented quality. With the CTG products, scientists are supported throughout their cell therapy development process.

    • Biolaminin 521 CTG (CT521)

      Full-length human recombinant laminin-521

      Biolaminin 521 CTG is a full-length laminin-521 substrate designed for clinical applications.
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    Other resources

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    • Neural cells

      Biorelevant culture of neural cells on Biolaminin substrates Laminins are widely expressed in the nervous system and are essential for […]
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    • Eye cells

      Biorelevant culture of eye cells on full-length laminin-521 Laminin proteins are integral components in the eye microenvironment Biolaminin products have […]
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    • Pluripotent stem cells

      Biorelevant culture of human ES and iPS cells on Biolaminin substrates Biolaminin 521 successfully replicates the genuine human stem cell niche […]
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    • 3D culture

      Biosilk and Biolaminin key advantages 3D cell culture and organoid formation 3D culture systems for disease modeling, drug screening, and […]
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    • Clinical applications and large-scale cell production

      Biolaminin substrates for large-scale manufacturing and clinical use Scaling up high-quality cell production for clinical needs A scalable system for […]
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