Resources & Instructions
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Application note 018: Modelling the kidney in 2D and 3D
Full-length Biolaminin® 521 and 511 enhance kidney disease models by supporting PSC-derived organoids, barrier integrity, and integration into kidney-on-a-chip platforms.
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Application overview: Culturing Animal PSCs on Biolaminin®️ 511 and 521
Discover how full-length Biolaminin® 511 and 521 enable robust, biologically relevant culture of animal pluripotent stem cells across species—supporting identity, reprogramming, and expansion in defined, feeder-free systems.
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Application note 003: Revolutionizing β-cell in culture
Discover how full-length Biolaminin 521, 511, and 411 revolutionize β-cell culture by enhancing differentiation, maturation, and functionality of PSC-derived and primary pancreatic islets. This guide highlights their role in improving glucose-stimulated insulin secretion, promoting cell survival, and recreating essential cell-matrix interactions for next-generation disease modeling and cell therapies
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Application overview: Next generation mesenchymal stromal cell culture with Biolaminin® 521
Biolaminin® 521 supports standardized, serum-free MSC and iMSC culture.
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Application note 024: Biofunctionalized hydrogels — Biolaminin® proteins for tissue-specific functionalization
This application note introduces how recombinant full-length laminins, Biolaminin® can be used to create tissue-specific hydrogels of various types, from natural to synthetic and for R&D or clinical translation. The biofunctionalization of the various hydrogels improve cell survival, attachment and differentiation of PSC-derived cells of the eye, liver, cardiac and vascular endothelium. The biofunctionalizatio […]
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Application note 009: Cardiomyocyte differentiation — on a combination of full-length Biolaminin® 521 (LN521) and Biolaminin 221 (LN221) substrates
Pluripotent stem cell (PSC)-derived cardiomyocytes play a key role in therapies of the future, serving directly as cellular therapy, as source material for tissue-specific extracellular vesicles, and as a platform for drug development. This requires standardized, reproducible, and efficient derivation of cardiomyocytes.This application note describes a published method on how to derive xeno-free and defined car […]
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Application note 004: Expansion of pluripotent stem cells on Biolaminin 521
Key benefits of Biolaminin for reproducible stem cell culture
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Application overview 008: Full-length laminin proteins are crucial for stem cells
Full-length laminins are crucial components in creating the stem cell niche in vivo and in vitro
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Application note 010: Hepatocyte differentiation on Biolaminin substrates
Full-length laminins support stem cell-derived differentiation and primary hepatocyte culture
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Instructions 004: Neural crest differentiation from hPSCs on Biolaminin® 521
Protocol for neural crest cell differentiation
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Application note 021: Neural Crest differentiation on Biolaminin® 521 substrate
Generation of hPSC-derived neural crest cells on Biolaminin 521
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Application note 023: Next generation xeno-free and defined skin cell culture – on Biolaminin® 521 (LN521) and Biolaminin 511 (LN511) substrates
Skin is the largest organ of the body and our first line of defense against pathogens and environmental impacts. The skin is composed of two main layers, epidermis and dermis. They are separated by an ultrathin basement membrane (BM), highly enriched in laminin proteins, particularly the isoforms 332, 331, 521 and 511. Laminin 332/331 are mostly associated with adhesion and […]
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