Publications
Here is a selection of publications where different laminin isoforms were used to create more authentic cell culture systems.
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Development of self-healing hydrogels to support choroidal endothelial cell transplantation for the treatment of early age related macular degeneration
Narendra G. Pandala et. al. Acta Biomaterialia, 2025
In retinal diseases such as age-related macular degeneration (AMD) and choroideremia, a key pathophysiologic step is loss of endothelial cells of th […]
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Embedded 3D Printing in Self‐Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs
Janko Kajtez et. al. Advanced Science, 2022
Human in vitro models of neural tissue with tunable microenvironment and defined spatial arrangement are needed to facilitate studies of brain devel […]
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A chemically defined and xeno-free hydrogel system for regenerative medicine
John Ong et. al. bioRxiv, 2025
Bio-fabricated scaffolds facilitate bona fide cellular interactions, cell-type specification, and the formation of three-dimensional tissue architec […]
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Metabolic switching, growth kinetics and cell yields in the scalable manufacture of stem cell-derived insulin-producing cells
Iworima et al. Stem Cell Research & Therapy, 2024
Background Diabetes is a disease affecting over 500 million people globally due to insulin insufficiency or insensitivity. For individuals with type […]
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Monolayer whole adherent islets: A novel tool for studying drug-induced diabetic phenotypes in vitro
Kumagai-Braesch et al. PLoS One, 2025
To understand the mechanisms of diabetes and develop novel drugs, various animal diabetes models as well as in vitro experimental systems have […]
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Expansion of induced pluripotent stem cells under consideration of bioengineering aspects: part 2
Teale et al. Applied Microbiology and Biotechnology, 2025
The manufacturing of allogeneic cell therapeutics based on human-induced pluripotent stem cells (hiPSCs) holds considerable potential to revolutioni […]
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Enhanced structure and function of human pluripotent stem cell-derived beta-cells cultured on extracellular matrix
Singh et al. Stem Cells Translational Medicine, 2021
The differentiation of human stem cells into insulin secreting beta-like cells holds great promise to treat diabetes. Current protocols drive stem c […]
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Recent studies show why stem cells need full-length laminin substrate
Recent articles highlighting human embryogenesis and intact laminin functionality show why stem cells prefer full-length laminin-521 substrate.
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Pluripotent stem cell-derived committed cardiac progenitors remuscularize damaged ischemic hearts and improve their function in pigs. npj Regenerative Medicine, 2023
Lynn Yap, Li Yen Chong, Clarissa Tan, Swarnaseetha Adusumalli, Millie Seow, Jing Guo, Zuhua Cai, Sze Jie Loo, Eric Lim, Ru San Tan, Elina Grishina, Poh Loong Soong, Narayan Lath, Lei Ye, Enrico Petretto & Karl Tryggvason.
Dr. Lynn Yap and colleagues present pre-clinical evidence of their promising myocardial infarction treatment using stem cell-derived committed cardi […]
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Observing Dynamic Conformational Changes within the Coiled-Coil Domain of Different Laminin Isoforms Using High-Speed Atomic Force Microscopy
Akter L, Flechsig H, Marchesi A, and Franz CM. Int. J. Mol. Sci. 2024
This study by Akter and colleagues provides a visual insight into the significance of using whole, full-length laminin to mimic biological condition […]
