Guideline

Stem cell culture matrices

Selecting the right cell culture substrate can be a painstaking and time-consuming task, because of the wide variety of products on the market, the lack of transparency when it comes to various components, and a large number of variables to consider for each application. This guide was created to help demystify the choices and simplify the selection process.

Developing a differentiation protocol that generates the target cell type at a sufficient quantity and purity and with high phenotypic maturity is challenging. The advancement from pre-clinical studies to a Phase 1 clinical trial requires a well-controlled production process and a safe and efficacious cell product. Now the important role of the extracellular matrix in shaping cell behavior is well recognized.