Why is using a biologically relevant matrix so important for your research?
Basement membranes (BM) are sheet-like extracellular matrix structures that are the foundation for cells to grow on. The BM composition is highly cell-surface selective and laminins are key proteins. In addition to their central role in BM structural organization, laminin is essential for modulation of vital cellular responses, such as cell adhesion, differentiation, migration, phenotype stability, and resistance to apoptosis. Without the right combination of laminin isoforms, cells and tissues become dysfunctional.
Biorelevance is about emphasizing nature. Our laminin cell culture matrices allow you to imitate the natural, cell-specific cell-matrix interaction in vitro, leading to enhanced cell maturation, cell organization, and improved cell functionality. We offer an expansive portfolio of chemically defined and animal origin-free laminin proteins for a variety of applications, including the reliable expansion of pluripotent cell and differentiation and maintenance of specialized cell types, such as hepatocytes, skeletal muscle cells, and different neural cells. The impact of our Biolaminin matrices on cell culture quality has been scientifically validated in many high-quality publications.