Cell–Matrix Interactions in Mammary Gland Development and Breast Cancer

Here, the authors argue that the interactions between mammary epithelial cells and their extracellular matrix (ECM) are crucial in the development and function of the tissue. Current strategies for treating breast cancer take advantage of our knowledge of the endocrine regulation and stromal–epithelial interactions. In addition, focusing on the microenvironmental influences that arise from cell-matrix interactions may open new opportunities for therapeutic intervention, suggesting a treatment where endocrine, growth factor, and cell-matrix interactions are targeted.