Functional diversity of laminins

Domogatskaya A., Rodin S., Tryggvason K.

Annu Rev Cell Dev Biol

In this review, the authors elucidate the evolution of laminins, describe their molecular complexity, and explore the current knowledge of their diversity and functional aspects, including laminin-mediated signaling via membrane receptors, in vitro cell biology, and involvement in various tissues gained from animal model and human disease studies. The potential use of laminins in cell biology research and biotechnology is discussed.