Laminin 411 acts as a potent inducer of umbilical cord mesenchymal stem cell differentiation into insulin-producing cells

Qu H., Liu X., Ni Y., Jiang Y., Feng X., Xiao J., Guo Y., Kong D., Li A., Li X., Zhuang X., Wang Z., Wang Y., Chang Y., Chen S., Kong F., Zhang X., Zhao S., Sun Y., Xu D., Wang D., Zheng C.

Journal of Translational Medicine, 2014

Efficient induction of differentiation to insulin-producing cells from MSCs. Up-regulated insulin expression at both mRNA and protein levels. Administration of the insulin-producing cells in T1 diabetes rats rapidly 1) down-regulated fasting blood glucose levels, 2) significantly reduced the HbA1c concentration and 3) markedly improved the symptoms and survival of the rats.