Laminin-511 expression is associated with the functionality of feeder cells in human embryonic stem cell culture
Hongisto H., Vuoristo S., Mikhailova A., Suuronen R., Virtanen I., Otonkoski T., Skottman H. Stem Cell Res., 2012
The authors of this study show that fibroblast feeders synthesize laminin-511 and that this is the main protein responsible for the maintenance of hESC pluripotency. This strengthens the already known biological function of laminin-511 and laminin-521 as the main cell-adhesion molecules for pluripotent stem cells.
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