Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes

Takayama K., Nagamoto Y., Mimura N., Tashiro K., Sakurai F., Tachibana M., Hayakawa T., Kawabata K., Mizuguchi H.  Cell Stem Cell Reports, 2013 

The authors of this important study demonstrated that laminin-111 is the optimal matrix for hepatoblasts. In addition to solving the need to efficiently expanding and purifying this liver progenitor, the matrix provides an important safety mechanism as LN-111 selectively only maintains hepatoblasts while eliminating residual undifferentiated cells that cannot survive and self-renew on laminin-111.