Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes

The authors of this important study demonstrated that laminin-111 is the optimal matrix for hepatoblasts. In addition to solving the need to efficiently expanding and purifying this liver progenitor, the matrix provides an important safety mechanism as LN-111 selectively only maintains hepatoblasts while eliminating residual undifferentiated cells that cannot survive and self-renew on laminin-111.