Neuronal Replacement as a Tool for Basal Ganglia Circuitry Repair: 40 Years in Perspective

Björklund A. and Parmar M.

Front. Cell. Neurosci., 2020

In this review article, the authors give an overview of past and current efforts to restore damaged connectivity in the adult mammalian brain using implants of fetal neuroblasts or stem cell-derived neuronal precursors. Focus on strategies aimed to repair damaged basal ganglia circuitry induced by lesions that mimic the pathology seen in humans affected by Parkinson’s or Huntington’s disease.