α6β1 and α7β1 Integrins Are Required in Schwann Cells to Sort Axons

Marta Pellegatta, Adèle De Arcangelis, Alessandra D’Urso, Alessandro Nodari, Desirée Zambroni, Monica Ghidinelli, Vittoria Matafora, Courtney Williamson, Elisabeth Georges-Labouesse, Jordan Kreidberg, Ulrike Mayer, Karen K. McKee, Peter D. Yurchenco, Angelo Quattrini, Lawrence Wrabetz and Maria Laura Feltri.

JNeurosci, 2013


In this article, all the α subunits that form predominant laminin-binding β1 integrins were deleted in Schwann cells. They conclude that α6β1 and α7β1 are the laminin-binding integrins required for axonal sorting. The basal lamina of Schwann cells contains especially laminins 211, 411 and 511.


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