Application note

Cardiomyocyte
differentiation

Discover how the combination of Biolaminin® 521 and 221 substrates enables efficient, defined, and xeno-free derivation of cardiovascular progenitor and cardiomyocyte populations from pluripotent stem cells. This optimized culture system doubles differentiation efficiency compared to other standardized substrates and promotes cell maturation with contractile and electrophysiological properties — supporting applications in disease modeling, drug discovery, and cardiac regeneration. 

What’s inside

  • Overview of PSC-derived cardiomyocytes and their therapeutic potential 
  • Defined, xeno-free differentiation using Biolaminin® 521 and 221 substrates 
  • Twice the efficiency of standard substrates for CVP and CM derivation 
  • Mature, functional cardiomyocytes displaying contraction and electrophysiological signatures 
  • Application in preclinical heart regeneration and translational research 
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