Application note

Efficient gene editing

Discover how Biolaminin® 521 provides a defined, animal-origin-free platform that enhances the efficiency and reproducibility of gene editing in human pluripotent stem cells (hPSCs). The biologically active, full-length laminin substrate supports optimal cell attachment, survival, and recovery post-transfection or transduction, enabling precise genetic modification and stable clonal expansion under fully defined conditions. 

What’s inside

  • Overview of gene editing workflows using Biolaminin® 521 
  • Improved cell survival and recovery following CRISPR/Cas9 or TALEN editing 
  • Enhanced single-cell cloning efficiency and culture stability 
  • Defined, animal-origin-free conditions minimizing variability and stress response 
  • Applications in disease modeling, functional genomics, and cell therapy development 
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