Application overview

Long-Term and Tissue-specific Organoids

Biosilk is a recombinant 3D microfiber network that mimics the structure and mechanics of natural extracellular matrix, enabling accurate, reproducible, and long-term organoid culture. When combined with full-length Biolaminin®, it creates tissue-specific microenvironments that support cell self-organization, migration, and maturation across a wide range of organoid and advanced 3D models.

What’s inside

• Overview of Biosilk’s strong, elastic microfiber network and its ECM-like permeability supporting nutrient and oxygen flow
• Tissue-specific organoid applications using Biosilk functionalized with different Biolaminin isoforms
• Evidence for improved survival, morphology, variability, and long-term stability across multiple organoid types
• Visual summaries of Biosilk + Biolaminin scaffold formation, hPSC integration, focal adhesion improvements, and multi-tissue 3D culture outcomes