
Webinar
Treating Blindness with Stem Cell Therapies
— With Dr. Laura Koivusalo, Professor Dr. Anders Kvanta, Dr. Fredrik Lanner, Dr. Stijn Heessen, Dr. Kristian Tryggvason, MBA and Dr. Susanna Teppo —
Highlights:
- We need (more) basic research and a broad approach
Several clinical trials show PSC therapies are safe, with early signs of long-term benefit — including promising follow-up data for LSCD. However, major challenges remain. Academic research is critical to better understand disease mechanisms, improve biomaterials for transplantation, and standardize cell identity markers. - Translating cell production from the lab to the clinic requires precision
Eye diseases are complex, and stem cell therapies are among the most advanced treatments being developed. Achieving GMP compliance and consistent manufacturing takes time and strategic planning. Starting with the end in mind is essential. - The cost of PSC therapies remain high, but there is optimism for the future
PSC therapies are still expensive, and investor and reimbursement incentives must be addressed early. Encouragingly, advances such as automation are paving the way for more scalable and cost-effective production.

StemSight Oy, Finland
Directed differentiation of hPSCs towards CEnCs under defined conditions – Cells 2021

Prof. Dr. Anders Kvanta, St Erik Eye Hospital, Sweden
Interim safety and efficacy of gene therapy for RLBP1-associated retinal dystrophy: a phase 1/2 trial – Nature Communications 2024

Dr. Fredrik Lanner, Karolinska Institute, Sweden
A comprehensive human embryo reference tool using single-cell RNA-sequencing data – Nature Methods 2024

Alder Therapeutics AB, Sweden
Photoreceptor laminin drives differentiation of hPSCs to photoreceptor progenitors – Molecular Therapy 2023