Applications – Neural cells

Neural cells

Biorelevant culture of neural cells on Biolaminin substrates

Laminins are widely expressed in the nervous system and are essential for the development and function of neural cells. Biolaminins allow a long-term culture of specialized neuronal cells and better purity of transplantable neural progenitors. See our infographic and information on specific cell types below.

Open Neural infographic

Biolaminin Key Advantages

Several laminin isoforms are expressed and functional in the nervous system. Biolaminins have successfully been used to mimic this authentic cell microenvironment for improved differentiation of the cell types in nervous system. Using Biolaminin 521, patient-derived iPSCs can be specified to neuroepithelial stem cell lines and efficiently expanded and differentiated into neurons and glial cells.

All our matrices are chemically defined and animal origin-free, which makes them ideal substrates for each level of the scientific process – from basic research to clinical applications.

Our products have consistent composition and quality. This enables minimized variability between experiments.

Numerous scientists have found our products and finally succeeded in their specific stem cell application. The power of full-length laminins incorporated into various cell systems is well documented in scientific articles and clinical trials.

What our customers say…

“We have discovered LN521 is far superior to all other alternative ECMs we have tried for hPSC culture, and have switched all our hiPSC and hESC lines to LN521 for maintenance. We’ve also found LN521 performs best for the adherence and regional specification of NPCs and neurons across several CNS differentiation protocols, including the dorsal cortex, medial ganglionic eminence, ventral midbrain, and ventral hindbrain.”

Dr. Jonathan Niclis
University of Copenhagen

See more testimonials

  • Biosilk

    3D culture substrate

    Biosilk is a recombinant 3D culture matrix that can be biofunctionalized with tissue-specific Biolaminin isoforms to create long-term organoids.
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  • Biosilk 521

    3D culture substrate

    Biosilk 521 is a recombinant 3D culture matrix biofunctionalized with Biolaminin 521 to create stem cell relevant niches for pluripotent (PSC) and […]
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  • Biolaminin 521 CTG (CT521)

    Full-length human recombinant laminin-521

    Biolaminin 521 CTG is a full-length laminin-521 substrate designed for clinical applications.
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  • Biolaminin 211 LN (LN211)

    Full-length human recombinant laminin-211

    Biolaminin 211 supports the growth, survival, and differentiation of a wide range of tissue-specific cell types, including motor neurons, cardiac ce […]
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  • Biolaminin 221 LN (LN221)

    Full-length human recombinant laminin-221

    Biolaminin 221 supports the growth, survival, and differentiation of a wide range of tissue-specific cell types, including cardiac cells and skeleta […]
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  • Biolaminin 111 LN (LN111)

    Full-length human recombinant laminin-111

    Biolaminin 111 is a full-length laminin-111 protein—an essential extracellular matrix component for many cell types in vivo. It has proven particu […]
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  • Biolaminin 121 LN (LN121)

    Full-length human recombinant laminin-121

    Biolaminin 121 is a full-length human laminin-121 protein that can be used as a general attachment protein for many cell types in […]
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